The cortical collecting duct plays a pivotal role in kidney local renin-angiotensin system
نویسندگان
چکیده
منابع مشابه
Reciprocal effect of angiotensin II in collecting duct renin synthesis.
ACTIVATION OF THE RENIN-ANGIOTENSIN system (RAS) plays a central role in the regulation of hypertension and sodium homeostasis. Angiotensin II (ANG II) is the most potent biologically active peptide that possesses pleiotropic functions to increase renal vascular resistance, cardiac contractility, aldosterone production, and enhanced sodium absorption in renal tubules, leading to elevated arteri...
متن کاملAngiotensin II stimulates epithelial sodium channels in the cortical collecting duct of the rat kidney.
We examined the effect of angiotensin II (ANG II) on epithelial Na(+) channel (ENaC) in the rat cortical collecting duct (CCD) with single-channel and the perforated whole cell patch-clamp recording. Application of 50 nM ANG II increased ENaC activity, defined by NP(o) (a product of channel numbers and open probability), and the amiloride-sensitive whole cell Na currents by twofold. The stimula...
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Chronic kidney diseases share common pathogenic mechanisms that, independently from the initial injury, lead to glomerular hyperfiltration, proteinuria, and progressive renal scarring and function loss. Inhibition of the renin angiotensin system (RAS) has been consistently found to reduce or halt the progressive deterioration of renal function through reduction of blood pressure and proteinuria...
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HEMORRHAGE has been shown by several investigators to increase aldosterone secretion in the normal man and dog. We therefore selected hemorrhage as a stimulus and studied the mechanism by which it increased aldosterone secretion. The development of a highly sensitive and specific isotope method for measuring aldosterone in adrenal vein blood by Kliman and Peterson' made these studies possible. ...
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We previously reported that mast cells express renin, the rate-limiting enzyme in the renin-angiotensin cascade. We have now assessed whether mast cell renin release triggers angiotensin formation in the airway. In isolated rat bronchial rings, mast cell degranulation released enzyme with angiotensin I-forming activity blocked by the selective renin inhibitor BILA2157. Local generation of angio...
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ژورنال
عنوان ژورنال: Orvosi Hetilap
سال: 2013
ISSN: 0030-6002,1788-6120
DOI: 10.1556/oh.2013.29597